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Insider Ownership

Name	Relationship / Title	Current Shares	Trading Activity
bb bioventures l p	Other	2,118,331	View
Date	Type	Shares Traded	Price Range USD
06/19/2008	Sell	155,800	19.90 - 20.00
06/17/2008	Sell	101,900	20.15 - 20.25
06/16/2008	Sell	281,149	20.05 - 20.46
02/08/2008	Sell	27,925	21.36
02/07/2008	Sell	36,664	23.02
02/04/2008	Acquisition (Non Open Market)	120,836	n/a
02/04/2008	Sell	27,300	23.86
02/04/2008	Disposition (Non Open Market)	1,500,000	n/a
05/02/2007	Option Execute	254,906	0.15
05/02/2007	Disposition (Non Open Market)	4,245	9.00
05/02/2007	Acquisition (Non Open Market)	962,818	n/a
05/02/2007	Buy	277,777	9.00
04/26/2007	Statement of Ownership	0	n/a
berrey m michelle	Officer	2,976	View
Date	Type	Shares Traded	Price Range USD
06/20/2008	Option Execute	2,976	4.20
05/19/2008	Option Execute	20,833	4.20
05/19/2008	Sell	20,833	18.00
burrill & co (life sciences gp), llc	Beneficial Owner (10% or more)	1,650,063	View
Date	Type	Shares Traded	Price Range USD
05/02/2007	Option Execute	212,099	0.15
05/02/2007	Acquisition (Non Open Market)	388,250	n/a
05/02/2007	Buy	222,222	9.00
04/26/2007	Statement of Ownership	0	n/a
burrill steven	Director	1,654,063	View
Date	Type	Shares Traded	Price Range USD
03/24/2009	Acquisition (Non Open Market)	2,000	n/a
09/24/2008	Acquisition (Non Open Market)	2,000	n/a
05/02/2007	Option Execute	212,099	0.15
05/02/2007	Acquisition (Non Open Market)	388,250	n/a
05/02/2007	Buy	222,222	9.00
04/26/2007	Statement of Ownership	0	n/a
carney william j	Director	68,666	View
Date	Type	Shares Traded	Price Range USD
01/25/2010	Option Execute	7,500	3.87 - 4.02
03/24/2009	Acquisition (Non Open Market)	2,000	n/a
09/24/2008	Acquisition (Non Open Market)	2,000	n/a
02/25/2008	Option Execute	26,667	3.00
04/26/2007	Statement of Ownership	0	n/a
conrad herbert j	Director	4,000	View
Date	Type	Shares Traded	Price Range USD
03/24/2009	Acquisition (Non Open Market)	2,000	n/a
09/24/2008	Acquisition (Non Open Market)	2,000	n/a
evnin luke	Other	2,089,394	View
Date	Type	Shares Traded	Price Range USD
06/23/2008	Sell	28,937	19.90 - 20.10
06/19/2008	Sell	155,800	19.90 - 20.00
gadicke ansbert	Beneficial Owner (10% or more)	0	View
Date	Type	Shares Traded	Price Range USD
06/16/2008	Sell	3,303	19.00 - 19.38
06/16/2008	Sell	15,676	19.00 - 19.38
06/13/2008	Sell	230	19.00
06/13/2008	Sell	1,091	19.00
06/10/2008	Sell	901	19.00 - 19.14
06/10/2008	Sell	4,274	19.00 - 19.14
06/05/2008	Sell	1,755	19.15
06/05/2008	Sell	8,328	19.15
05/02/2007	Option Execute	254,906	0.15
05/02/2007	Disposition (Non Open Market)	4,245	9.00
05/02/2007	Acquisition (Non Open Market)	962,818	n/a
05/02/2007	Buy	277,777	9.00
04/26/2007	Statement of Ownership	0	n/a
galakatos nicholas	Beneficial Owner (10% or more)	0	View
Date	Type	Shares Traded	Price Range USD
02/21/2008	Sell	304	17.54
02/21/2008	Sell	10,632	17.54
goll alexandra	Director	0	View
Date	Type	Shares Traded	Price Range USD
04/26/2007	Statement of Ownership	0	n/a
hahn elliot f	Director	17,333	View
Date	Type	Shares Traded	Price Range USD
03/24/2009	Acquisition (Non Open Market)	2,000	n/a
09/24/2008	Acquisition (Non Open Market)	2,000	n/a
04/26/2007	Statement of Ownership	0	n/a
henner dennis	Beneficial Owner (10% or more)	0	View
Date	Type	Shares Traded	Price Range USD
04/02/2008	Sell	745	20.00
04/02/2008	Sell	4,645	20.00
inouye michael k	Director	6,500	View
Date	Type	Shares Traded	Price Range USD
03/24/2009	Acquisition (Non Open Market)	2,000	n/a
02/27/2009	Buy	1,250	10.07 - 10.11
02/26/2009	Buy	1,250	10.59 - 10.68
09/24/2008	Acquisition (Non Open Market)	2,000	n/a
leutzinger kurt	Officer	207,250	View
Date	Type	Shares Traded	Price Range USD
03/13/2008	Buy	1,000	16.32
03/12/2008	Buy	4,000	15.60
08/09/2007	Option Execute	20,833	3.00
04/26/2007	Statement of Ownership	0	n/a
lubetkin paul	Officer	500	View
Date	Type	Shares Traded	Price Range USD
02/25/2009	Buy	500	10.14 - 10.65
mpm bioventures iii llc	Beneficial Owner (10% or more)	0	View
Date	Type	Shares Traded	Price Range USD
04/26/2007	Statement of Ownership	0	n/a
mpm bioventures iii-qp l.p.	Beneficial Owner (10% or more)	4,061	View
Date	Type	Shares Traded	Price Range USD
02/08/2008	Sell	6,874	21.36
02/07/2008	Sell	17,450	23.02
02/04/2008	Acquisition (Non Open Market)	100,673	n/a
02/04/2008	Sell	12,993	23.86
02/04/2008	Disposition (Non Open Market)	713,912	n/a
05/02/2007	Option Execute	215,683	0.15
05/02/2007	Disposition (Non Open Market)	3,592	9.00
05/02/2007	Acquisition (Non Open Market)	607,085	n/a
05/02/2007	Buy	277,777	9.00
otto michael j.	Officer	2,410	View
Date	Type	Shares Traded	Price Range USD
09/18/2009	Option Execute	40,000	3.87
09/18/2009	Sell	40,000	21.90 - 21.97
08/11/2008	Option Execute	5,835	3.00
08/11/2008	Sell	5,835	21.06 - 21.82
05/27/2008	Option Execute	81,264	3.00 - 6.00
05/27/2008	Sell	81,264	17.50 - 18.09
04/07/2008	Option Execute	100	6.00
04/07/2008	Sell	100	20.00
04/04/2008	Option Execute	400	6.00
04/04/2008	Sell	400	20.00
04/02/2008	Option Execute	37,900	2.55 - 6.00
04/02/2008	Sell	37,900	20.00 - 20.05
09/05/2007	Option Execute	10,000	3.00
04/26/2007	Statement of Ownership	0	n/a
price fredric d	Director	30,666	View
Date	Type	Shares Traded	Price Range USD
03/03/2010	Option Execute	1,668	5.45
12/04/2009	Option Execute	1,666	5.45
09/02/2009	Option Execute	1,666	5.45
06/01/2009	Option Execute	21,666	5.45
03/24/2009	Acquisition (Non Open Market)	2,000	n/a
09/24/2008	Acquisition (Non Open Market)	2,000	n/a
price p schaefer	Officer	383,283	View
Date	Type	Shares Traded	Price Range USD
04/26/2007	Statement of Ownership	0	n/a
qvt associates gp llc	Beneficial Owner (10% or more)	2,793,274	View
Date	Type	Shares Traded	Price Range USD
09/24/2009	Sell	800,000	20.88
09/23/2009	Sell	10,000	22.41
09/22/2009	Sell	100,000	22.95
02/04/2009	Statement of Ownership	0	n/a
rogers michael d.	Officer	0	View
Date	Type	Shares Traded	Price Range USD
11/13/2008	Sell	2,901	18.62 - 18.75
11/13/2008	Option Execute	16,672	13.88
11/13/2008	Sell	13,771	18.00 - 18.59
11/04/2008	Option Execute	500	13.88
11/04/2008	Sell	500	18.02 - 18.25
11/03/2008	Option Execute	1,578	13.88
11/03/2008	Sell	1,578	18.00
schinazi raymond f	Beneficial Owner (10% or more)	1,289,156	View
Date	Type	Shares Traded	Price Range USD
05/02/2007	Acquisition (Non Open Market)	246,119	n/a
04/26/2007	Statement of Ownership	0	n/a
04/26/2007	Statement of Ownership	0	n/a
simon nicholas j iii	Beneficial Owner (10% or more)	0	View
Date	Type	Shares Traded	Price Range USD
04/02/2008	Sell	43	20.00
04/02/2008	Sell	5,074	20.00
02/08/2008	Sell	6,874	21.36
02/07/2008	Sell	17,450	23.02
02/04/2008	Acquisition (Non Open Market)	100,673	n/a
02/04/2008	Sell	12,993	23.86
02/04/2008	Disposition (Non Open Market)	713,912	n/a
05/02/2007	Option Execute	215,683	0.15
05/02/2007	Disposition (Non Open Market)	3,592	9.00
05/02/2007	Acquisition (Non Open Market)	607,085	n/a
05/02/2007	Buy	277,777	9.00
04/26/2007	Statement of Ownership	0	n/a
tvm iv gmbh & co kg	Beneficial Owner (10% or more)	977,802	View
Date	Type	Shares Traded	Price Range USD
04/27/2007	Option Execute	52,302	0.10
04/27/2007	Disposition (Non Open Market)	872	9.00
04/27/2007	Acquisition (Non Open Market)	250,121	n/a
04/26/2007	Statement of Ownership	0	n/a
tvm v life science ventures gmbh & co kg	Beneficial Owner (10% or more)	750,023	View
Date	Type	Shares Traded	Price Range USD
04/27/2007	Option Execute	98,043	0.10
04/27/2007	Disposition (Non Open Market)	1,635	9.00
04/27/2007	Acquisition (Non Open Market)	176,476	n/a
04/27/2007	Buy	111,111	9.00
04/26/2007	Statement of Ownership	0	n/a
williamson robert f iii	Director	10,666	View
Date	Type	Shares Traded	Price Range USD
03/24/2009	Acquisition (Non Open Market)	2,000	n/a
09/24/2008	Acquisition (Non Open Market)	2,000	n/a
04/26/2007	Statement of Ownership	0	n/a

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