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Insider Ownership

Name	Relationship / Title	Current Shares	Trading Activity
bb bioventures l p	Beneficial Owner (10% or more)	0	View
Date	Type	Shares Traded	Price Range USD
02/08/2008	Sell	27,925	21.36
02/07/2008	Sell	36,664	23.02
02/04/2008	Acquisition (Non Open Market)	120,836	n/a
02/04/2008	Sell	27,300	23.86
02/04/2008	Disposition (Non Open Market)	1,500,000	n/a
05/02/2007	Option Execute	254,906	0.15
05/02/2007	Disposition (Non Open Market)	4,245	9.00
05/02/2007	Acquisition (Non Open Market)	962,818	n/a
05/02/2007	Buy	277,777	9.00
04/26/2007	Statement of Ownership	0	n/a
berrey m michelle	Officer	20,833	View
Date	Type	Shares Traded	Price Range USD
05/19/2008	Option Execute	20,833	4.20
05/19/2008	Sell	20,833	18.00
burrill & co (life sciences gp), llc	Beneficial Owner (10% or more)	1,650,063	View
Date	Type	Shares Traded	Price Range USD
05/02/2007	Option Execute	212,099	0.15
05/02/2007	Acquisition (Non Open Market)	388,250	n/a
05/02/2007	Buy	222,222	9.00
04/26/2007	Statement of Ownership	0	n/a
burrill steven	Director	1,650,063	View
Date	Type	Shares Traded	Price Range USD
05/02/2007	Option Execute	212,099	0.15
05/02/2007	Acquisition (Non Open Market)	388,250	n/a
05/02/2007	Buy	222,222	9.00
04/26/2007	Statement of Ownership	0	n/a
carney william j	Director	57,166	View
Date	Type	Shares Traded	Price Range USD
02/25/2008	Option Execute	26,667	3.00
04/26/2007	Statement of Ownership	0	n/a
gadicke ansbert	Director	2,858,150	View
Date	Type	Shares Traded	Price Range USD
05/02/2007	Option Execute	254,906	0.15
05/02/2007	Disposition (Non Open Market)	4,245	9.00
05/02/2007	Acquisition (Non Open Market)	962,818	n/a
05/02/2007	Buy	277,777	9.00
04/26/2007	Statement of Ownership	0	n/a
galakatos nicholas	Beneficial Owner (10% or more)	0	View
Date	Type	Shares Traded	Price Range USD
02/21/2008	Sell	304	17.54
02/21/2008	Sell	10,632	17.54
goll alexandra	Director	0	View
Date	Type	Shares Traded	Price Range USD
04/26/2007	Statement of Ownership	0	n/a
hahn elliot f	Director	13,333	View
Date	Type	Shares Traded	Price Range USD
04/26/2007	Statement of Ownership	0	n/a
henner dennis	Beneficial Owner (10% or more)	0	View
Date	Type	Shares Traded	Price Range USD
04/02/2008	Sell	745	20.00
04/02/2008	Sell	4,645	20.00
leutzinger kurt	Officer	207,250	View
Date	Type	Shares Traded	Price Range USD
03/13/2008	Buy	1,000	16.32
03/12/2008	Buy	4,000	15.60
08/09/2007	Option Execute	20,833	3.00
04/26/2007	Statement of Ownership	0	n/a
mpm bioventures iii llc	Beneficial Owner (10% or more)	830,823	View
Date	Type	Shares Traded	Price Range USD
04/26/2007	Statement of Ownership	0	n/a
mpm bioventures iii qp lp	Beneficial Owner (10% or more)	4,061	View
Date	Type	Shares Traded	Price Range USD
02/08/2008	Sell	6,874	21.36
02/07/2008	Sell	17,450	23.02
02/04/2008	Acquisition (Non Open Market)	100,673	n/a
02/04/2008	Sell	12,993	23.86
02/04/2008	Disposition (Non Open Market)	713,912	n/a
05/02/2007	Option Execute	215,683	0.15
05/02/2007	Disposition (Non Open Market)	3,592	9.00
05/02/2007	Acquisition (Non Open Market)	607,085	n/a
05/02/2007	Buy	277,777	9.00
otto michael	Officer	19,600	View
Date	Type	Shares Traded	Price Range USD
04/07/2008	Option Execute	100	6.00
04/07/2008	Sell	100	20.00
04/04/2008	Option Execute	400	6.00
04/04/2008	Sell	400	20.00
04/02/2008	Option Execute	37,900	2.55 - 6.00
04/02/2008	Sell	37,900	20.00 - 20.05
09/05/2007	Option Execute	10,000	3.00
04/26/2007	Statement of Ownership	0	n/a
price p schaefer	Officer	383,283	View
Date	Type	Shares Traded	Price Range USD
04/26/2007	Statement of Ownership	0	n/a
schinazi raymond f	Beneficial Owner (10% or more)	1,289,156	View
Date	Type	Shares Traded	Price Range USD
05/02/2007	Acquisition (Non Open Market)	246,119	n/a
04/26/2007	Statement of Ownership	0	n/a
04/26/2007	Statement of Ownership	0	n/a
simon nicholas j iii	Beneficial Owner (10% or more)	0	View
Date	Type	Shares Traded	Price Range USD
04/02/2008	Sell	43	20.00
04/02/2008	Sell	5,074	20.00
02/08/2008	Sell	6,874	21.36
02/07/2008	Sell	17,450	23.02
02/04/2008	Acquisition (Non Open Market)	100,673	n/a
02/04/2008	Sell	12,993	23.86
02/04/2008	Disposition (Non Open Market)	713,912	n/a
05/02/2007	Option Execute	215,683	0.15
05/02/2007	Disposition (Non Open Market)	3,592	9.00
05/02/2007	Acquisition (Non Open Market)	607,085	n/a
05/02/2007	Buy	277,777	9.00
04/26/2007	Statement of Ownership	0	n/a
tvm iv gmbh & co kg	Beneficial Owner (10% or more)	978,674	View
Date	Type	Shares Traded	Price Range USD
04/27/2007	Option Execute	52,302	0.10
04/27/2007	Disposition (Non Open Market)	872	9.00
04/27/2007	Acquisition (Non Open Market)	250,121	n/a
04/26/2007	Statement of Ownership	0	n/a
tvm v life science ventures gmbh & co kg	Beneficial Owner (10% or more)	751,658	View
Date	Type	Shares Traded	Price Range USD
04/27/2007	Option Execute	98,043	0.10
04/27/2007	Disposition (Non Open Market)	1,635	9.00
04/27/2007	Acquisition (Non Open Market)	176,476	n/a
04/27/2007	Buy	111,111	9.00
04/26/2007	Statement of Ownership	0	n/a
williamson robert f iii	Director	6,667	View
Date	Type	Shares Traded	Price Range USD
04/26/2007	Statement of Ownership	0	n/a

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