Insider Ownership

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Name	Relationship / Title	Current Shares	Trading Activity
berrey m michelle	Officer	0	View
Date	Type	Shares Traded	Price Range USD
12/01/2011	Option Execute	6,252	6.84 - 10.83
12/01/2011	Sell	6,252	130.33
11/01/2011	Option Execute	3,124	6.84
11/01/2011	Sell	3,124	74.56
09/01/2011	Option Execute	3,124	10.83
09/01/2011	Sell	3,124	65.63
08/01/2011	Option Execute	937	18.60
08/01/2011	Sell	937	119.99
07/01/2011	Option Execute	938	18.60
07/01/2011	Sell	938	111.83
04/27/2011	Option Execute	50,103	4.20 - 21.65
04/27/2011	Sell	50,103	100.60
06/17/2010	Sell	2,976	32.53
06/20/2008	Option Execute	2,976	4.20
05/19/2008	Option Execute	20,833	4.20
05/19/2008	Sell	20,833	18.00
Burrill & Co (life Sciences gp), llc	Beneficial Owner (10% or more)	1,650,063	View
Date	Type	Shares Traded	Price Range USD
05/02/2007	Option Execute	212,099	0.15
05/02/2007	Acquisition (Non Open Market)	388,250	n/a
05/02/2007	Buy	222,222	9.00
04/26/2007	Statement of Ownership	0	n/a
carney william j	Director	146,330	View
Date	Type	Shares Traded	Price Range USD
10/11/2011	Acquisition (Non Open Market)	1,000	n/a
03/23/2011	Acquisition (Non Open Market)	2,000	n/a
03/18/2010	Acquisition (Non Open Market)	2,000	n/a
01/25/2010	Option Execute	7,500	3.87 - 4.02
03/24/2009	Acquisition (Non Open Market)	2,000	n/a
09/24/2008	Acquisition (Non Open Market)	2,000	n/a
02/25/2008	Option Execute	26,667	3.00
04/26/2007	Statement of Ownership	0	n/a
conrad herbert j	Director	17,000	View
Date	Type	Shares Traded	Price Range USD
10/11/2011	Acquisition (Non Open Market)	1,000	n/a
05/03/2011	Option Execute	40,000	17.55
05/03/2011	Sell	40,000	99.04
03/23/2011	Acquisition (Non Open Market)	2,000	n/a
03/18/2010	Acquisition (Non Open Market)	2,000	n/a
03/24/2009	Acquisition (Non Open Market)	2,000	n/a
09/24/2008	Acquisition (Non Open Market)	2,000	n/a
hahn elliot f	Director	43,666	View
Date	Type	Shares Traded	Price Range USD
10/11/2011	Acquisition (Non Open Market)	1,000	n/a
03/23/2011	Acquisition (Non Open Market)	2,000	n/a
12/20/2010	Option Execute	43,125	13.67 - 21.65
09/30/2010	Option Execute	24,666	3.00 - 4.02
09/17/2010	Option Execute	30,000	3.00 - 6.75
03/18/2010	Acquisition (Non Open Market)	2,000	n/a
03/24/2009	Acquisition (Non Open Market)	2,000	n/a
09/24/2008	Acquisition (Non Open Market)	2,000	n/a
04/26/2007	Statement of Ownership	0	n/a
inouye michael k	Director	22,000	View
Date	Type	Shares Traded	Price Range USD
10/11/2011	Acquisition (Non Open Market)	1,000	n/a
03/23/2011	Acquisition (Non Open Market)	2,000	n/a
03/18/2010	Acquisition (Non Open Market)	2,000	n/a
03/24/2009	Acquisition (Non Open Market)	2,000	n/a
02/27/2009	Buy	1,250	10.07 - 10.11
02/26/2009	Buy	1,250	10.59 - 10.68
09/24/2008	Acquisition (Non Open Market)	2,000	n/a
leutzinger kurt	Officer	186,417	View
Date	Type	Shares Traded	Price Range USD
05/06/2011	Sell	11,287	102.88
05/05/2011	Sell	9,546	102.61
03/13/2008	Buy	1,000	16.32
03/12/2008	Buy	4,000	15.60
08/09/2007	Option Execute	20,833	3.00
04/26/2007	Statement of Ownership	0	n/a
otto michael j.	Officer	0	View
Date	Type	Shares Traded	Price Range USD
11/01/2011	Option Execute	17,500	10.83
11/01/2011	Sell	17,500	74.56
08/01/2011	Option Execute	8,929	18.60
08/01/2011	Sell	8,929	119.99
04/28/2011	Sell	9,500	99.85
03/22/2011	Option Execute	6,279	13.67
03/22/2011	Sell	6,279	64.00
10/01/2010	Sell	5,000	29.50
09/28/2010	Option Execute	7,811	4.02
09/28/2010	Sell	12,811	29.50
07/01/2010	Option Execute	7,189	4.02
09/18/2009	Option Execute	40,000	3.87
09/18/2009	Sell	40,000	21.90 - 21.97
08/11/2008	Option Execute	5,835	3.00
08/11/2008	Sell	5,835	21.06 - 21.82
05/27/2008	Option Execute	81,264	3.00 - 6.00
05/27/2008	Sell	81,264	17.50 - 18.09
04/07/2008	Option Execute	100	6.00
04/07/2008	Sell	100	20.00
04/04/2008	Option Execute	400	6.00
04/04/2008	Sell	400	20.00
04/02/2008	Option Execute	37,900	2.55 - 6.00
04/02/2008	Sell	37,900	20.00 - 20.05
09/05/2007	Option Execute	10,000	3.00
04/26/2007	Statement of Ownership	0	n/a
price p schaefer	Officer	766,564	View
Date	Type	Shares Traded	Price Range USD
10/03/2011	Option Execute	40,000	1.50
10/03/2011	Sell	40,000	79.33
09/01/2011	Option Execute	40,000	1.50
09/01/2011	Sell	40,000	65.63
08/01/2011	Option Execute	20,000	3.00
08/01/2011	Sell	20,000	120.15
07/01/2011	Option Execute	20,000	3.00
07/01/2011	Sell	20,000	110.47
06/01/2011	Option Execute	20,000	3.00
06/01/2011	Sell	20,000	100.54
04/26/2007	Statement of Ownership	0	n/a
rogers michael d.	Officer	0	View
Date	Type	Shares Traded	Price Range USD
05/09/2011	Option Execute	10,000	13.88
05/09/2011	Sell	10,000	109.08
04/27/2011	Option Execute	20,000	13.88
04/27/2011	Sell	20,000	99.00
11/13/2008	Sell	2,901	18.62 - 18.75
11/13/2008	Option Execute	16,672	13.88
11/13/2008	Sell	13,771	18.00 - 18.59
11/04/2008	Option Execute	500	13.88
11/04/2008	Sell	500	18.02 - 18.25
11/03/2008	Option Execute	1,578	13.88
11/03/2008	Sell	1,578	18.00
schinazi raymond f	Beneficial Owner (10% or more)	1,955,823	View
Date	Type	Shares Traded	Price Range USD
05/02/2007	Acquisition (Non Open Market)	246,119	n/a
04/26/2007	Statement of Ownership	0	n/a
04/26/2007	Statement of Ownership	0	n/a
williamson robert f iii	Director	7,000	View
Date	Type	Shares Traded	Price Range USD
10/11/2011	Acquisition (Non Open Market)	1,000	n/a
05/06/2011	Option Execute	20,000	3.00
05/06/2011	Sell	31,666	104.36
03/23/2011	Acquisition (Non Open Market)	2,000	n/a
03/18/2010	Acquisition (Non Open Market)	2,000	n/a
03/24/2009	Acquisition (Non Open Market)	2,000	n/a
09/24/2008	Acquisition (Non Open Market)	2,000	n/a
04/26/2007	Statement of Ownership	0	n/a

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